Based on details of the entorhinalвЂ“hippocampal connections, we propose that there will be differences in the modulation of firing patterns along the transverse axis in CA1 and the subiculum. They might also serve a unique role in memory, but they receive little attention.Дetailed anatomical knowledge lies at the basis of the discovery of grid cells that are important for navigation. However, there are also recurrent networks in the hilus of the dentate gyrus, CA1 and the subiculum. The CA3 recurrent network is the most prominent auto-associative network in the hippocampus and is implicated in pattern-separation and pattern-completion tasks that are relevant for memory. Based on the connections observed in the interactive diagram of the knowledge base, we pose that the entorhinal cortex associates information prehippocampally at a more generic level than the HF. Generally it is thought that only the HF is involved in memory formation, through associating different types of information. The role of some of these underexposed connections is discussed in relation to three topics that are strongly associated with the PHRвЂ“HF network: memory formation, navigation and temporal dynamics. Using this knowledge base, the PHRвЂ“HF circuitry is discussed and special attention is paid to underexposed connections. We present a comprehensive interactive knowledge base of all anatomically established PHRвЂ“HF connections in the rat.

Although the anatomical connections between and within the hippocampal formation (HF) and the parahippocampal region (PHR) have been and still are being investigated extensively, for several reasons some of the PHRвЂ“HF network connections have become underexposed and this probably results in biased functional concepts. Comprehensive knowledge of the architecture of neuronal networks lies at the basis of understanding their functions.

Hippocampus anatomy diagram ca1 ca2 ca3